The Elimination Effect of Propofol on Reactive Oxygen Species in Patients with Acute Craniocerebral Injury
- VernacularTitle:丙泊酚对急性颅脑损伤患者体内活性氧的清除作用
- Author:
Min LIANG
;
Xiaobin WEI
- Publication Type:Journal Article
- Keywords:
Reactive oxygen species;
Acute craniocerebral injury;
Propofol
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the elimination effect of propofol on the reactive oxygen species(ROS) in patients with acute craniocerebral injury (ACI). Methods Forty patients with ACI were randomly divided into propofol group receiving propofol anesthesia and ?-OH group as control . Electron spin resonance(ESR) spectroscopy was used to determine the plasma contents of oxygen free radical (OFR), and the plasma contents of lipid peroxides(LPO) and nitrogen oxide (NO) were determined with chemical method. Blood samples were collected before anesthesia and 2, 4 hours after starting operation. Results The plasma contents of NO, OFR and LPO significantly increased before operation in patients with ACI compared with healthy subjects(all P
