The Effect of IL-6 and IL-8 on the MMP-9 Secretion of Endometrial Stromal Cells in Women with Endometriosis
- VernacularTitle:IL-6和IL-8对子宫异位内膜基质细胞分泌MMP-9的影响
- Author:
Min FANG
;
Fuxian HE
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Endometrial stromal cell;
Interleukin-6;
Interleukin-8;
MMP-9
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of IL-6 and IL-8 on the MMP-9 secretion of endometrial stromal cells in women with endometriosis to explore the function of IL-6 and IL-8 in the adherence and planting process of ectopic endometrium. Methods The endometrial stromal cells were cultured in DMEM/F12 medium containing different concentrations of IL-6 or IL-8 for 24 hours, then the media were collected to measure the levels of MMP-9 by ELISA. Results The levels of MMP-9 in control stromal cells cultured with high concentration of IL-6 were significantly higher than those without IL-6 (P
