Expression and Significance of Cyclooxygenase-2 in Cervical,Endometrial and Ovarian Cancers
- VernacularTitle:子宫颈、子宫内膜和卵巢癌中COX-2的测定及其意义
- Author:
Wenhui YU
;
Xiaomei ZHOU
;
Zhuohua LI
- Publication Type:Journal Article
- Keywords:
Cyclooxygenase-2;
Immunofluorescence;
Cervical cancer;
Endometrial cancer;
Ovarian cancer
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study cyclooxygenase-2 (COX-2) expression levels in cervical, endometrial and ovarian cancers as well as their originated normal tissues. Methods Semiquantitative immunofluorescent assay (IFA) was used to detect COX-2 expression levels in cervical squamous cell carcinoma (n=12),endometrial adenocarcinoma (n=13),and ovarian serous adenocarcinoma (n=9). COX-2 expression levels in normal cervical (n=14),endometrial (n=15),and ovarian (n=13) tissues were simultaneously detected as control. Results Normal cervical tissues expressed COX-2 more frequently than cervical cancers (50% vs 23%), but the difference was not signicant (P=0.247). The positive rate of COX-2 expression was significantly higher in endometrial adenocarcinomas (69%) than that in normal endometrium (7%) (P
