Correlation Analysis Between the VEGF Expression and Chemotherapeutic Efficacy in Patients with Oral Squamous Cell Carcinoma
- VernacularTitle:口腔癌术前化疗效果与血管内皮生长因子表达的相关分析
- Author:
Xinrong OU
;
Xinchun JIAN
;
Zhigang YAO
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Squamous cell carcinoma;
Mouth;
Treatment
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between the chemotherapeutic efficacy and VEGF expression in the patients with oral squamous cell carcinoma. Methods 51 cases with oral squamous cell carcinoma who received preoperative chemotherapy of a total 80mg pingyangmycin were enrolled in this study. The relationship among the chemotherapeutic effect, VEGF expression, fever, and the duration of fever was analyzed using linear correlation, stepwise regression and student t-test. Results VEGF expression in the cancer cells of 92.1%(47/51) patients decreased after preoperative chemotherapy, and the decreased expression of VEGF was not significantly correlated with chemotherapentic efficacy. But the chemotherapeutic effect was closely related with fever degree in the early stage of chemotherapy. Conclusion There was no significant relationship between chemotherapeutic effects and VEGF expression in oral squamous cell carcinoma. Fever in early stage of chemotherapy may serve as an index for evaluating the patient prognosis.
