Study on the Anti-oxidative Action of Melatonin on the Oxidative Damage Model of Brain Tissues of Mice
- VernacularTitle:褪黑素对脑组织氧化损伤模型小鼠的抗氧化作用研究
- Author:
Mengliang JIA
;
Chun DONG
- Publication Type:Journal Article
- Keywords:
Melatonin;
Glutamic acid;
Antioxidation radical;
Aging
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the counteraction of melatonin(MT)on the oxidative damage model of brain tissues of mice caused by glutamic acid.METHODS:The mice were randomly divided into blank group,model group and melatonin(MT)(high dosage and low dosage)group.Drugs were injected(by intraperitoneal injection)into the mice of the MT group in advance for7days.Each group were injected with glutamic acid through lateral ventricle to form models,levels of MDA and GSH and the activity of GSH-PX of each group were determined.RESULTS:There was a significant increase in the level of MDA(P
