Study on Identification Problems of the Pharmacokinetic Models
- VernacularTitle:药动学模型的辨识问题研究
- Author:
Lu ZHOU
- Publication Type:Journal Article
- Keywords:
Pharmacokinetics;
Compartment models;
Identification problems;
Therapeutic drug monitoring
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the identification problems of pharmacokinetic compartment models.METHODS:Problems of the identification of classical compartment models in single administration were systematically discussed by Laplace transformation method.RESULTS:The classical compartment models in single administration don't have the character of u-niqueness and the identification for which is a problem.CONCLUSION:The drug level in plasma and the concentration of drugs that distributed in organs were in a direct ratio under the condition of two kinds of unidentifiable classical compartment models,in that case,it has theoretic bases and significance to predict the concentration of drugs that distributed in organs or target organs by means of determining the drug concentration in plasma;if on the other hand,if two kinds of classical com-partment models are identifiable,the drug level in plasma and the concentration of drugs that distributed in organs or target organs wouldn't be in a proportional relationship,in this case,it is advisable to make sure the relationship between the drug le_ vel in plasma and the concentration of drugs that distributed in organs or target organs before predicting drug concentration that distributed in organs or target organs by means of monitoring the drug concentration in plasma;otherwise,it is baseless and meaningless.
