Determination of Salivary Drug Concentration of Gentamicin and Its Clinic Significance
- VernacularTitle:庆大霉素唾液药物浓度测定及临床意义
- Author:
Jing HE
- Publication Type:Journal Article
- Keywords:
Gentamicin;
Salivary drug concentration;
blood drug level
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the correlation between salivary drug concentration and blood,drug level its clinic sig-nificance.METHODS:The salivary drug concentration and blood drug level of gentamicin of15volunteer cases were deter-mined by radioimmunoassay.RESULTS:Both blood drug level and salivary drug concentration of gentamicin reached to peak level1hour after medication.CONCLUSION:The blood drug level of gentamicin and the salivary drug concentration of gentamicin are positively correlated,i.e.it is possible for salivary to substitute for blood in the therapeutic drug monitoring of gentamicin.
