Relationship between tumor metastasis-related genes and adenomyosis
- VernacularTitle:子宫腺肌症与肿瘤转移相关基因之间关系的研究
- Author:
Lina KONG
;
Qing SUN
;
Yonghong LUO
;
Huafeng DING
;
Tiechen LI
;
Linmin LU
- Publication Type:Journal Article
- Keywords:
Endometriosis;
MMPs;
TIMPs;
nm23-H1;
Immunohistochemistry
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the tumor metastasis-related genes expression in adenomyosis and normal endometrium in order to investigate the pathogenesis of adenomyosis. METHODS: 43 specimens of adenomyosis, 22 specimens of controls (normal endometrium) were studied. The expressions of nm23-H1, MMP-2, MMP-9, MT1-MMP, and TIMP-1 in adenomyosis and controls were detected by immunohistochemical method. RESULTS: The expression levels of MMP-2, MMP-9, and MT1-MMP in adenomyosis were significantly higher than those in controls ( P 0 05). CONCLUSION: MMP-2, MMP-9, especially MT1-MMP, maybe play an important role in the pathogenesis of adenomyosis.
