Comparison of the Inhibition Effects of Arsenacetylic Acid on Experimental H_(22) Hepatoma-Bearing Mice in Two Different Forms of Administration
- VernacularTitle:2种给药方式的胂酸基乙酸对H_(22)肝癌荷瘤小鼠的抑瘤作用比较
- Author:
Lixia GUO
;
Yuanliang WANG
;
Juan XIN
;
Yan XIANG
;
Rong WANG
- Publication Type:Journal Article
- Keywords:
Tumor bearing mice;
ASAC;
Liver cancer;
Forms of drug administration.
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To compare inhibition effects of arsenacetylic acid(ASAC) on experimental H22 hepatoma-bearing mice in different forms of administration. METHODS: The mice were divided into 5 groups at random after inoculated with H22 hepatoma into their right axillas hypodermic by intraperitoneal injection(ip) and intravenous injection(iv), and then injected with normal saline,cyclophosphamide and different dosage of ASAC, observe the rate of tumor strain becoming tumor, the inhibition effects of the subjects and the effects of the subjects on mice's viscera. RESULTS: Compared with ip,either high, moderate or low dosage of ASAC by iv did have an obvious inhibitory effect on tumor and the tumor inhibition rates were 46.59%, 46.31% and 32.48% respectively; however, the spleen index in groups that of lower dosage of ASAC by two forms of drug administration were increased; there were death by poisoning in the group that iv with high dosage of ASAC.CONCLUSION: Compared with ip, the administration of ASAC by iv has a better effect on tumor.
