Study on Distribution in Mouse of Tetrandrine Polylactic Acid Microsphere in Vivo
- VernacularTitle:汉防己甲素聚乳酸微球小鼠肺靶向研究
- Author:
Guohua CHENG
;
Jiabo LUO
- Publication Type:Journal Article
- Keywords:
Tetrandrine;
Microsphere;
Distribution in vivo
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the lung targeted characteristic of tetrandrine polylactic acid microsphere(TPM).MET_HODS:TPM and tetrandrine injection were injected intravenously into mouse,an RP-HPLC was established to measure the content of TPM in biological samples,and the concentrations of tetrandrine in different tissues of mice were determined and compared.RESULTS:The determinable concentration of tetrandrine in plasma was in the linear range of 0.519～17.000?g/ml(r=0.9 996),the recovery was 97.32%,the mean value of RSD was 4.46%.After the use of TPM,the concentrations of tetrandrine in mouse tissues were significantly higher than tetrandrine injection,and the highest concentration was detected in lungs of mouse.CONCLUSIONS:TPM is distinguishingly lung targeted.
