Expression of placental vascular growth factor in pregnancy-induced hypertension
- VernacularTitle:胎盘血管生长因子在妊娠高血压综合征的表达及意义
- Author:
Zhiying HU
;
Marong FANG
;
Yiping WANG
- Publication Type:Journal Article
- Keywords:
Pregnancy complications, cardiovascular;
Hypertension;
Vascular endothelial growth factor A;
Fibroblast growth factor-2;
Placenta
- From:
Chinese Journal of Perinatal Medicine
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of vascular growth factors including vascular endothelial growth factor(VEGF), basic fibroblast growth factor(bFGF) and platelet-derived growth factor (p-DGF) in placentae of pregnancy-induced hypertension(PIH) patients and their significance. Methods Placental tissues of 15 normal gravidas and 19 PIH women were collected. The expression of vascular growth factors were detected by immunohistochemistry (PAP) combined with the analysis of computer microphotography. Results The average grey value difference (GVD) of VEGF was 61.6?3.7 in moderate and severe PIH group, which was significantly lower than that of the normal control group (71.1?5.8) and mild PIH (70.9?8.9, P
