Study of the relationships between endothelial nitric-oxide synthase polymorphism and pregnancy induced hypertension
- VernacularTitle:一氧化氮合酶基因多态性与妊娠高血压综合征的关系
- Author:
Xia CAI
;
Jing ZHAO
;
Yonghui JIAO
- Publication Type:Journal Article
- Keywords:
Nitric-oxide synthase;
Polymorphism(genetics);
Pregnancy complications, cardiovascular;
Hypertension
- From:
Chinese Journal of Perinatal Medicine
1998;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the gene polymorphism of endothelial nitric-oxide synthase(eNOS) with pregnancy induced hypertension(PIH). Methods Sixty-six gravidas with PIH and 91 normal pregnant women(control) in the third trimester were investigated. The G894T mutation at exon 7 of the endothelial nitric-oxide synthase gene was studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequencies of eNOS GG, GT and TT genotypes were 62.1%, 34.8% and 3.1% in PIH group and (79.1%,) 20.9% and 0.0% in control group, respectively (P0.05). Conclusions The variant (G-T) of 894 polymorphism site of eNOS is associated with the genesis of PIH, but not related to the severity of PIH. T allele may be a susceptible gene to PIH.
