Relationship between the expression of Tiam1, Rac1 and the pathobiological behavior of gastric cancer
- VernacularTitle:Tiam1和Rac1表达与胃癌病理生物学行为的关系
- Author:
Jinming ZHU
;
Peiwu YU
;
Yongliang ZHAO
- Publication Type:Journal Article
- Keywords:
STOMACH NEOPLASMS/pathol;
TIAM1;
RAC1;
NEOPLASMS, METASTASIS
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of T lymphoma invasion and (metastasis) inducing factor 1 (Tiam1), ras-related C3 botulinum toxin substrate 1 (Rac1) with the invasion and metastasis of gastric cancer. Methods The expressions of Tiam1 and Rac1 proteins in 60 cases of (gastric) cancer and paracarcioma gastric mucosa tissues were detected using Strept Avidin-Biotin Complex(SABC) immunohistochemical method,and the correlation between the expression of Tiam1, Rac1 and (clinicopathological) parameters of gastric cancer were analysed. Results (1)There was negative staining of Tiam1 protein in paracarcioma gastric mucosa tissues, while positive staining was detected in gastric cancer (tissues)(78.33%)(P 0.05). (4) The expression of Rac1 in patients with positive staining of Tiam1 was significantlyhigher than that in patients with negative staining(P
