A study of the correlation and expression of PTEN ,VEGF and MMP-9 in human gastric carcinoma
- VernacularTitle:胃癌组织中PTEN,VEGF,MMP-9的表达及相关性研究
- Author:
Rongfang HE
;
Zhongliang HU
;
Ming SHEN
;
Jifang WEN
- Publication Type:Journal Article
- Keywords:
STOMACH NEOPLASMS/pathol;
ONCOGENE PROTEINS EXPRESSION;
PTEN;
VEGF;
MMP-9
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the expression of PTEN ,vascular endothelial growth factor(VEGF)and (matrix) metalloproteinase 9(MMP-9) in gastric carcinoma and its relationship to the biological behavior of (gastric) carcinoma. Methods The expression of PTEN ,VEGF and MMP-9 in 71 cases of gastric carcinoma tissue and 37 cases of gastric mucosa distant from carcinoma were detected by streptavidin peroxidase (immunohistochemistry). Results The expression of PTEN in gastric carcinoma tissues(71.8%) was (significantly) lower than its expression in gastric mucosa distant from carcinoma(100%)(P0.05).The expression of VEGF in gastric carcinoma(62.5%) was sigificantly higher than in gastric mucosa distant from carcinoma(29.7%)(P0.05).The expression of MMP-9 in gastric (carcinoma)(69%) was significantly higer than in gastric mucosa distant form carcinoma(40.5%)(P0.05).The expression of PTEN in gastric carcinoma was inversely correlated with expression of VEGF and MMP-9(P
