Expression of Vascular Endothelial Growth Factor and its Receptor in Patients with Psoriasis Vulgaris
- VernacularTitle:血管内皮生长因子及其受体在银屑病发病中的作用及意义
- Author:
Xibao ZHANG
;
Quan LUO
;
Zhihua WU
;
Shaoqian CHEN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Endothelial growth factors;
Receptor,growth factor;
Neovascularization,pathologic
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the relationship between angiogenesis and vascular endothelial growth factor (VEGF) and its receptor in patients with psoriasis. Methods The expression of VEGF and its receptor KDR, and micro-vascular density (MVD) were measured in 42 patients with psoriasis vulgaris and 15 normal controls by in situ hybridization and immunohistochemistry technique, respectively. The concentration of VEGF in sera was measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in patients with psoriasis vulgaris and normal controls. Results ①The expression of VEGF mRNA and its protein, KDR, and MVD in psoriatic lesions were significantly higher than those in the normal controls (P
