Expression of Pituitary Adenylate Cyclase Activating Polypeptide and its Receptor in Psoriatic Lesions and Non-lesional Skins
- VernacularTitle:银屑病皮损及非皮损中垂体腺苷酸环化酶激活肽及其受体的研究
- Author:
Lijun ZHANG
;
Xueqin YANG
;
Rusong MENG
;
You LI
;
Li JIANG
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Pituitary adenylate cyclase activating polypeptide
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptor (PACAP-R) on the pathogenesis of psoriasis. Methods The expression of PACAP and PACAP-R in the skin from 10 normal controls, 25 psoriatic lesions and non-lesional skins was measured by immunohistochemical technique. Results The expression of PACAP and PACAP-R was significantly lower in the psoriatic lesional skins than that of the non-lesional skins. The area density and mean absorbance of PACAP and PACAP-R in the lesional skins were significantly lower compared with those in the non-lesional skins (P
