Study on the Effects of Qiweikaixin Granules on the Behaviors of Brain Injured-Olfactory Bulb Damage Type Rats and on the Contents of ACTH and COR in Plasma
- VernacularTitle:七味开心颗粒对脑损伤-嗅球破坏模型大鼠行为及血浆中ACTH、COR含量的影响
- Author:
Xiaohe ZHENG
;
Jiayu HOU
;
Jianning SUN
;
Xiankun WANG
- Publication Type:Journal Article
- Keywords:
Qiweikaixin granules;
Depression;
Brain injury-olfactory bulb damage type;
Open field test;
Heliophobic test;
Subthalamus-pituitary-adrenal cortex axis
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the pharmacological action of Qiweikaixin Granules.METHODS:Brain injured-olfac?tory bulb damage type was adopted,and the rats were divided into normal control group,pseudo-operation group,model group,hydrochloric acid clomipramine group and Qiweikaixin Granules(high,moderate,mild dosage)group,the behaviors of each group was observed,the contents of adrenocorticotrophic hormone corticotrophin(ACTH)and cortisol(COR)in plasma were also observed.RESULTS:In both the open field test and the heliophobic test,the behaviors of the model group had obvious changes;both the Qiweikaixin Granule group and the hydrochloric acid clomipramine group significantly resisted the change of behaviors of rats;the contents of ACTH and COR in the plasma of the model rats group increased significantly(P
