Relationship between Drug Serum Concentrations and Two Kinds of Dosage Regimen
- VernacularTitle:奈替米星2种给药方案血药浓度的比较
- Author:
Yuhong XU
;
Yuzhen LI
;
Zhao ZHANG
;
Ying HE
- Publication Type:Journal Article
- Keywords:
Netilmicin;
Drug serum concentration;
Dosage regimen
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the clinical effects and toxicity of netilmicin with different administrations by de?termining its serum concentration in the treatment of lower respiratory tract infection.METHODS:22cases of lower respi?ratory tract infection were randomly divided into two groups.The drug serum concentrations were determined by TDx system.Clinical effects were compared;renal function and hearing ability were monitored.RESULTS:On the condition of the same total daily dosage,the peak concentrations in once-daily group(group QD)were significantly higher than those in twice-daily group(group BD)(P