Study on the Restraining Factors in the Intravenous Immune Globulin(IVIG)Bacterial Endotoxin Test
- VernacularTitle:静脉注射人免疫球蛋白细菌内毒素检查的抑制因素研究
- Author:
Xiumei LI
;
Lin ZHOU
- Publication Type:Journal Article
- Keywords:
Intravenous immune globulin(IVIG);
Bacterial endotoxin test(BET);
Restraining factor
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the restraining factors in the intravenous immune globulin(IVIG.)bacterial endotoxin test.METHODS:A series tests were designed;the sensitivity of limulus was checked and the limit of endotoxin was validated;the effects of vehicle and pH value on the IVIG endotoxin test results were observed so as to find out the chief restraining factors of this test method.RESULTS:Lower pH value has an inhibition effect on the in IVIG bacterial endotoxin test.CONCLUSION:Bacterial endotoxin test can replace the rabbit testing method in the pyrogen test of IVIG.When the condition of lower pH is changed.
