Expression and Significance of mdr_1mRNA in Guinea Pig Cochlea Lateral Wall at Different Developmental Stages
- VernacularTitle:不同发育阶段豚鼠耳蜗外侧壁中mdr_1mRNA的表达及其意义
- Author:
Xueyuan ZHANG
;
Yaguang ZHOU
- Publication Type:Journal Article
- Keywords:
Multidrug resistance 1( mdr 1);
Cochlea;
Lateral wall;
Extrusive traffic
- From:
Journal of Audiology and Speech Pathology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression and the significance of mdr 1 mRNA in guinea pig cochlea lateral wall at different developmental stages.Methods Thirty white guinea pigs with red eye including three developmental stages were used in this study. The expression of mdr 1mRNA in the cochlear lateral wall was measured in situ hybridization and analyzed by the softeware of MPLAS-500.Results mdr 1mRNA was detected mainly in the endothelial cells.The expression intensity of mdr 1mRNA was different in guinea pig cochlea lateral wall at different developmental stages, mdr 1mRNA in 1～2 weeks group was significantly lower than that of 3-week-group and 4-week-group(P0.05).Conclusion mdr 1mRNA is found in the normal cochlea lateral wall cells. The expression intensity is different with the development of guinea pig cochlea lateral wall.
