Expression of CD158 in refractory chronic graft-versus- host diseases treated with tacrolimus,mycophenolate mofetil combined with met hylprednisone
- VernacularTitle:CD158分子表达在他克莫司、霉酚酸酯联合甲基强的松龙治疗顽固性慢性移植物抗宿主病中的追踪观察
- Author:
Chun CHEN
;
Jianpei FANG
;
Lianning DUAN
;
Jing WEI
;
Shaoliang HUANG
- Publication Type:Journal Article
- Keywords:
CD158;
T-lymphocytes;
Graft vs host dis ease;
Tacrolimus;
Mycophenolic acid;
Methylprednisolone
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the sequence expression o f CD158 molecule after tacrolimus (FK506), mycophenolate mofetil (MMF) combined with methylprednisone (MP) treatment for refractory chronic graft-versus-host di seases (cGVHD). METHODS: The efficacy and the side effect were observed in 6 chi ld patients with extensive cGVHD after allogeneic hematopoietic stem cell transp lantation treated with the combination of FK506, MMF and MP, meanwhile the chang es of the CD158 expressions on T lymphocytes and NK cells in peripheral blood be fore and after treatment were observed. RESULTS: The expression of CD4+CD158a+ and CD4+CD158b+ were very low before and after transplantation and treatment, there was no stati stical significance. The expression of CD3+CD158b+ and CD3+CD8+CD158b + were 4.97%?2.36% and 4.58%?2.90% respectively in five patients with acut e GVHD, and there was statistical significance compared with that of before-tran splantation (P
