Protection of extract of Radix Atragali composite against acute hepatic injury
- VernacularTitle:复方黄芪提取物抗急性肝损伤作用的研究
- Author:
Hua XU
;
Jie WEN
;
Liping YU
;
Xiaoming YANG
;
Jizhou XIANG
- Publication Type:Journal Article
- Keywords:
Liver injury;
Extracts of Radix Atragali;
Galactosamine;
Carbon tetrachloride
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protection of extract of Radix Atragali composite against acute hepatic injury. METHODS: Fed with the extract of Radix Atragali composite, m ice were injected with D-galactosamine intraperitoneally (800 mg/kg) and rats were i njected with carbon tetrachloride hypodermically (5 mL/kg) to induce acute hepat ic injury on the 8th day. ALT, AST and bilirubin in serum were examined. Patholo gical changes of liver tissue were observed. RESULTS: Compared with model group, activities of ALT and AST, c oncentrations of bilirubin were markedly decreased and pathological scores also showed that degeneration and necrosis of hepatic cell were lighter in the the ex tract of Radix Atragali composite treatment group. CONCLUSION: The extract of Radix Atragali composite attenuat es hepatic injury induced by D-galactosamine or carbon tetrachloride.
