Protective effect of mesenteric lymph duct ligation on organ functions in MODS rats
- VernacularTitle:肠系膜淋巴管结扎对MODS大鼠的器官保护作用
- Author:
Zigang ZHAO
;
Chunyu NIU
;
Jing ZHANG
;
Gui FAN
;
Shuqiang WANG
;
Yuzhen WANG
- Publication Type:Journal Article
- Keywords:
Multiple organ failure;
Lymphatic system;
Lig ation
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effect of mese nt eric lymph duct ligation on the functions of liver, kidney and heart, and morpho logy in multiple organ dysfunction syndrome (MODS) rats subjected to two-hit. METHODS: Male Wistar rats were divided into three groups: the me senteric lymph duct ligation group, the non-ligation group and sham group. The M ODS model of two-hit was established by bleeding and LPS administration in both ligation group and non-ligation group. After 24 h, all rats were cannulated to f acilitate blood withdrawal for serum sample, then all rats were killed and organ s including kidney, liver, lung and heart were collected for making microscopic sectio ns. The biochemical indexes of hepatic and renal functions and myocardial enzyme in s erum were determined before and after experiment. RESULTS: After two-hit, the serum contents of AST, ALT, TBA, BUN , Cr and LDH-1 in both non-ligation group and ligation group, and UA content in non-ligation group were obviously increased than those in pre-experiment and sh am group (P
