Expression of MKP-1 in myocardium of hypertensive rat at different ages and its effect on myocardial hypertrophy
- VernacularTitle:不同年龄高血压大鼠心肌中MKP-1的表达及对心肌肥厚的影响
- Author:
Shan LI
;
Zhong LIU
;
Jianhua ZHU
;
Chaoyang HUANG
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
Mitogen-activated protein kinase phosphatase;
Mitogen- activated protein kinases;
Hypertension;
Rats;
Myocardial hypertrophy
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of mitog en -activated protein kinase phosphatase-1 (MKP-1) in cardiac ventricle muscles of spontane ously hypertensive rats and Wistar Kyoto rats at different ages and the relati onship between MKP-1 and myocardial hypertrophy. METHODS: The ratio of left ventricle weight to body weight (LVW/ BW) was measured to reflect myocardial hypertrophy. Protein expression of p-ERK was detected by Western blotting. MKP-1 mRNA in cardiac ventricle muscles was ex amined by RT-PCR. RESULTS: (1) The blood pressure (P
