Effect of hyperhomocysteine on endothelial cell function in rabbits
- VernacularTitle:兔饮食所致高同型半胱氨酸血症血管内皮功能的实验研究
- Author:
Yunfei BIAN
;
Diaoqing GAO
;
Fen GAO
;
Chuanshi XIAO
- Publication Type:Journal Article
- Keywords:
Hyperhomocysteinemia;
Endothelium, vascular;
Folic acid;
Vitamin B 12
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of hyperhomo cysteine on endothelial cell function. METHODS: By establishing hyperhomocysteinemia model, 18 male New Zealand rabbits were divided into control group (control group) and high-methi o nine-diet group (M group). At the end of 3 weeks, M group was divided again into M+0 group (continuing high methionine-diet) and M+F group (high-methionine-diet plus folic acid, vitamin B 12). At the end of 6 weeks, isolated aortic rin g s were made and the maximum vasodilation of the aortic rings to Ach was investig ated. Meanwhile, the plasma concentrations of Hcy, NO, ET-1, Ang II at 0 week, 3 weeks and 6 weeks and the contents of NO 2-/NO 3-, Ang Ⅱ, ET-1, NOS i n regional vascular tissue at 8 weeks were also measured. RESULTS: (1) In contrast to M+F group and control group, the max imum vasodilation to Ach were decreased (E max=26.73?4.51 vs 47.84 ?5.62, 56.42?7.82, P
