Effects of NOS2 inhibitor on left ventricular morphologic and haemodynamic parameters after myocardial infarction in rats
- VernacularTitle:一氧化氮合酶2抑制剂对大鼠心肌梗死后左心室形态及心功能的影响
- Author:
Bin ZHENG
;
Linsheng CAO
;
Qiutang ZENG
;
Dazhu LI
;
Xiang WANG
- Publication Type:Journal Article
- Keywords:
Rats;
Nitric-oxide synthase;
Myocardial infar ction;
Ventricular function, left
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the role of NOS2 in the devel op ment of cardiac dysfunction after rat myocardial infarction by observing effects of S-methylisothiourea (SMT) on left ventricular morphology and haemodynamics. METHODS: An selective NOS2 inhibitor, was used. Administration o f SMT by gavage began 30 min before coronary ligation. Six weeks later, left ventricular morphologic and haemodynamic parameters were o bserved,and NOS2 expression, plasma NO 2-/NO 3- level and myocardial fibr osis were studied. RESULTS: Six weeks after myocardial infarction, NOS2 level in ra t non-infarct cardiac muscle, plasma NO 2-/NO 3- level, CVP and LVEDP were higher than that in controls. Long term administration of SMT decreased plasma NO 2-/NO 3- level [(26.6?6.1) ?mol/L vs (50.1?10.4) ?mol/L, P
