The protective effect of cistanche deserticola Y.C Ma . on thymocytes in septic rats
- VernacularTitle:肉苁蓉对败血症大鼠胸腺细胞的保护作用
- Author:
Li XIAO
;
Zhiqiang WANG
- Publication Type:Journal Article
- Keywords:
Cistanche deserticola Y C Ma;
Sepsis;
T hymus gland;
Mitochondria
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protective effect of ci stanche deserticola Y. C Ma. on thymocytes in septic rats. METHODS: Cecum ligation perforation (CLP) was used to induce sep sis. Treatment group was treated with cistanche deserticola Y. C Ma. (1.25 g?kg -1?d -1, ig) for 14 days before CLP. Animals were killed 12 h or 24 h after CLP an d thmocyte s were collected. The ratio of thmocyte apoptosis and mitochondrial membrane pot ential were determined by the flow cytometry. The ATP activity was detected by s pectrophotography. RESULTS: The rate of thmocyte apoptosis significantly increased 12 h after CLP. The ATP activity decreased 24 h after CLP was significant. The extract of desert living cistanche effectively repressed the apoptosis of th ymocytes and maintained the mitochondrial membrane potential. CONCLUSIONS: The extract of cistanche deserticola Y. C Ma. p rotects thymocytes against apoptosis induced by sepsis. Maintaining of mitochond rial membrane potential may be the protective mechanism.
