Antagonistic effects of aminophylline on airway inflammation and oxidative lung tissue damage in chronic hypoxic rats
- VernacularTitle:氨茶碱对慢性间断低氧大鼠气道炎症及肺组织氧化损伤拮抗作用的探讨
- Author:
Hong ZHANG
;
Hongyu ZHANG
;
Baosen PANG
;
Chengqing XIA
;
Shujie NIU
;
Li MA
;
Yanling MAO
;
Ping XIN
;
Xiuxia HUANG
;
Haiyan ZHANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Inflammation;
Oxidant;
Aminophylline;
Lung
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of chronic hy poxia and antagonistic effects of aminophylline on airway inflammation and oxida tive lung damage in rats. METHODS: Thirty-four male Wistar rats were randomly divided into three groups: normal control group (n=10); hypoxia group (n=12); aminop hlline-treated group (n=12). The last two groups were both exposed to hypoxi a 7 hours per day for 21 days. The third group was treated with aminophlline (1 00 mg?kg -1?d -1) before exposed to hypoxia. The level of tumor ne c rosis factor (TNF) -?, interleukin (IL)-10, lipid peroxide (LPO) and the activi ty of superoxide dismutase (SOD) were determined in blood and homogenates of lung tissue. RESULTS: Compared to the control group, the levels of TNF-?, IL -10 and LPO were significantly increased (P
