A Study on the Metabolic Changes of CuZnSOD in Gastric Carcinoma and Gastric Ulcer Tissues
- VernacularTitle:胃癌和胃溃疡病组织中CuZnSOD代谢变化关系的研究
- Author:
Shaohong WANG
;
Jieqing PENG
;
Kejun FANG
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
Gastric ulcer;
Superoxide dismutase;
Image analysis
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the metabolic changes of the Cu-Zn-superoxide dismutase (CuZnSOD) and pathogenesis of the gastric carcinoma and gastric ulcer. Methods CuZnSOD activity was measured in the 52 gastric carcinoma tissues and 10 gastric ulcer tissues. The distribution and expression level of CuZnSOD in the tissues were detected by immunohistochemical staining and density analysis, respectively. Results CuZnSOD activities in the gastric carcinoma and ulcer tissues were 17.73?1.74～62.85?8.47NU/mg protein and 71.73?6.01 NU/mg protein, respectively. CuZnSOD activities in the gastric far-end tissues of the gastric carcinoma and ulcer were 25.10?3.58 ～ 101.50?11.06 NU/mg protein and 139.67?8.80 NU/mg protein, respectively. The density scales of CuZnSOD expression in the gastric carcinoma cells and tissues were 83.83?7.28 ～ 145.25?8.84 and 124.67?6.30 ～ 146.13?8.51, respectively. There was not CuZnSOD expression in the gastric ulcer tissue, while the density scales of CuZnSOD expression in the normal gastric tissue was 144.60?7.32. Conclusion The metabolic change of CuZnSOD in the gastric carcinoma tissue was related with the histological classification and differentiation of gastric carcinoma. The ability of anti-oxidation obviously declined in the both local carcinoma tissues and extensive gastric tissues. However, the ability of anti-oxidation declined only in the center of gastric ulcer.
