The Effect of Ligustrazini on I?B Kinase-? Expression in Acute Lung Injury Induced by Hemorrhagic Shock in Rabbits
- VernacularTitle:川芎嗪对失血性休克再灌注肺损伤I?B激酶-?表达的调节干预研究
- Author:
Xiaomin HU
;
Wen YIN
;
Yuecai LI
- Publication Type:Journal Article
- Keywords:
Hemorrhagic shock;
Acute lung injury;
Ligustrazini
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of I?B kinase-?(IKK-?) and the protective effect of Ligustrazini(Lig) in acute lung injury(ALI) induced by hemorrhagic shock(HS) in rabbits. Methods Thirty rabbits were randomly divided into three groups: HS plus endotoxin group(n=10), Lig treatment group(n=10) and the normal group(n=10). In situ hybridization and immunohitochemistry combined with in situ quantitative analysis were used to detect the distribution and relative contents of IKK-? and NF-?B in lung tissues. The plasma concentration of tumor necrosis factor-?(TNF-?) was measured by ELISA. Morphological change of the lung was observed by light microscopy. Results Compared with the normal group, the expression levels of IKK-?(0.223?0.080), NF-?B(0.162?0.021), and TNF-?(809.33?201.6) were obviously increased in HS plus endotoxin group(P
