The Effect of Gaoyuankang Capsule on the Serum NO Content and Plasma ANP, CGRP and ET Content in Entrants Landing at High Altitude Rapidly
- VernacularTitle:高原康胶囊对快速进入高原者血清NO及血浆三参数的影响及意义
- Author:
Suzhi LI
;
Bihai ZHENG
;
Hongbin WANG
- Publication Type:Journal Article
- Keywords:
Gaoyuankang capsules;
Nitric oxide;
Atrial natriuretic peptide;
Calcitonin gene-related peptide;
Endothelin
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Gaoyuankang capsule on the serum nitric oxide (NO) content and plasma atrial natriuretic peptide(ANP), calcitonin gene-related peptide(CGRP) and endothelin(ET) content in great numbers of entrants landing at high altitude rapidly and its significance. Methods 2150 new soldiers, who swiftly entered plateau by air from plain, were randomly divided into experimental group (EG,n=1150) and control group (CG,n=1000). EG continually orally took Gaoyuankang capsules for 3 days before boading a plane. CG orally took placebo. The changes of serum NO content and plasma ANP, CGRP and ET content before and after entering plateau, and the incidence of acute high altitude disease (AHAD) after entering plateau were compared between the two groups, each group containing 40 randomly selected soldiers. Results NO and CGRP concentration of CG remarkably decreased after entering plateau than before entering plateau, while ANP and ET levels remarkably increased after entering plateau than before entering plateau (P
