Mutation Analysis for Mitochondrial DNA in a Chinese Pedigree with Maternally Inherited Aminoglycoside Antibiotic-Induced Deafness
- VernacularTitle:母系遗传氨基糖苷类抗生素致聋家系的线粒体DNA突变分析
- Author:
Shayan WANG
;
Guofeng GAO
;
Ruanzhang ZHANG
- Publication Type:Journal Article
- Keywords:
Maternally Inherited;
Mitochondrial DNA;
Aminoglycoside;
Gene mutation
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect mutation of mitochondrial DNA in a chinese pedgree with maternally inherited aminoglycoside antibiotic-induced deafness. Methods The mutation of mitochondrial DNA from all 18 family members of a chinese pedigree with maternally inherited aminoglycoside antibiotic-induced deafness was detected by PCR and DNA sequencing. Results Nine individuals in this pedigree carried A→G mutation at the 1555th bp of mitochondrial 125 rRNA, and the others did not have this mutation. Conclusion Mitochondrial DNA mutation may be one of major factors resulted in aminoglycoside antibiotic-induced deafness in this pedigree.
