Elementary Evaluation of the Safety of Chitosan DCX-16
- VernacularTitle:壳聚糖DCX-16的初步安全性评价
- Author:
Jian ZENG
;
Xiaohui LI
;
Yuehua HUANG
;
Haigang ZHANG
;
Shuhui LI
- Publication Type:Journal Article
- Keywords:
Chitosan DCX-16;
cell toxicity;
local irritating effect;
3T3cell
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the safety of Chitosan DCX-16elementarily.METHODS:DCX-16was injected i.p.to observe the acute toxicity in mice.The local irritating effects were observed on tolerance test,cerato-conjunctiva and muscles stimulus test in rabbits.The cell shape and proliferative rate of3T3cells were determinated by MTT in cell culture with DCX-16.RESULTS:It showed that DCX-16had no irritation on the eyes and muscles in rabbits.Tolerance dose of DCX-16in mice was as high as3.0g/kg per day.Cell culture with DCX-16demonstrated that3T3cell's shape and growth were normal.The relative growth rate of3T3cells had no statistical difference between control and DCX-16groups on the2nd,3rd,4th day.CONCLUSION:DCX-16is safe.
