Protective Effect of Total Flavone of Abelmoschl Manihot L Medic on Acute Myocardial Ischemic-anoxic Injury in Mice
- VernacularTitle:黄蜀葵花总黄酮对小鼠急性心肌缺血缺氧损伤的保护作用
- Author:
Li FAN
;
Liping YUAN
;
Zhiwu CHEN
;
Chuangeng MA
- Publication Type:Journal Article
- Keywords:
TFA;
Myocardial ischemic-anoxic injury;
Isoproterenol;
Trachea clamping
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the protective effect of total flavone of Abelmoschl Manihot L medic(TFA)on acute myocardial ischemic and anoxic injury in mice.METHODS:Acute myocardial ischemic model induced by subcutaneous injection of Isoproterenol was adopted to observe the effects of TFA on the abnormal ST segment in lead II and T wave on ECG,my?ocardial water content(MWC)and myocardial index(MI);Moreover the effect of TFA on myocardial anoxic tolerance was ob?served in trachea clamping mice.RESULTS:TFA could remarkably ameliorate the abnormal changes of ECG and significantly inhibit the increase of MWC and MI of model group.It was found that the ECG lasting time was much longer in the groups pretreated with TFA.CONCLUSION:TFA plays a protective role in myocardial ischemia and anoxic injury in mice.
