Effect of ERK1/2 on ischemic preconditioning in diabetic rat hearts
- VernacularTitle:细胞外信号调节的蛋白激酶对糖尿病大鼠心肌缺血预处理的影响
- Author:
Caiyun MA
;
Like ZHANG
;
Fenghe DU
;
Lingqiao LU
;
Hongxia WANG
;
Xiangjun ZENG
;
Ping FU
;
Qingqing MAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Ischemic preconditioning;
Mitogen-activated protein kinases
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To test the effect of ERK1/2 on ischemic preconditioning (IPC) in diabetic rat hearts. METHODS: The diabetic rat model was made with alloxan. After eight weeks, 24 rats were divided into 4 groups: non-diabetic IPC rats (group A); non-diabetic non-IPC rats (group B); diabetic IPC rats (group C); diabetic non-IPC rats (group D). ECGⅡ lead, left ventricular development pressure (LVDP), and first derivative of LVDP ~(?dp/dt_~max ) were recorded. Myocardial phosphorylation of extracellular signal regulated kinases1/2 (ERK1/2) was detected by Western-blotting. RESULTS: (1) The ventricular arrythmia score was significantly lower in group A than that in group C (P
