Effect of taurine on action potentials and ATP-sensitive posstiaum channel activity during hypoxia in ventricular muscle of guinea pig
- VernacularTitle:牛磺酸对低氧条件下豚鼠心室肌细胞动作电位和ATP敏感性钾电流的影响
- Author:
Fen ZHU
;
Jihua MA
;
Peihua ZHANG
- Publication Type:Journal Article
- Keywords:
Taurine;
Anoxia;
Myocardium;
Cells;
Action potentials;
Potassium channels
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of taurine on ATP sensitive potassium channel (IK_~-ATP ) during hypoxia in single ventricular myocyte. METHODS: The model of myocardial hypoxia was induced by unmixed and saturated nitrogen. IK_~-ATP activities were measured by whole-cell patch clamp recording. RESULTS: Activities of IK_~-ATP in the cell membrane of hypoxia ventricular myocyte significantly increased, compared to that in the normal. Extracellular injection of taurine (5,10,20 mmol/L) inhibited the increase in the IK_~-ATP activity in the hypoxia myocardium in a concentration-depend manner. Injection of taurine also recovered shorten APD during hypoxia. CONCLUSIONS: Taurine produces its cardioprotective effect by inhibiting the activity of IK_~-ATP in the hypoxia cardiomycytes of guinea pig. The results suggest that the depletion of taurine during myocardial hypoxia contributes to the early activation of the K_~ATP channel. [
