Role of PKC and MMPs in the pathogenesis of the rat experimental atherosclerosis and the action of Danshen injection
- VernacularTitle:PKC和MMPs在实验性大鼠动脉粥样硬化形成中的作用及丹参的作用机制
- Author:
Chuanyi WANG
;
Huaiqin ZHANG
;
Yili ZHANG
;
Hao ZHOU
;
Shanggong LI
;
Lixin XU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases;
Arteriosclerosis;
Protein kinase C;
Salvia miltiorrhiza
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of protein kinase C on the expression of MMPs that may play an important role in the formation of atherosclerosis and the possible mechanism of Danshen injection to treat atherosclerosis. METHODS: 50 Sprgue-Dawley (SD) rats were divided into three groups randomly: control group (group C), model group (group M) and Denshen treatment group (group D). The serum was collected to measure the level of cholesterol, triglyceride, low density lipoprotein cholesterol(LDL-ch). The expression of PKC and MMPs were measured by immunohistochemistry. Light microscope and electron microscope were also used. RESULTS: ① The cholesterol, triglyceride, LDL-ch concentrations in group M and group D were significantly higher than those in group C (P
