Polymorphisms in IL-4 and IL-4R genes in children with allergic asthma
- VernacularTitle:白细胞介素4和受体基因多态性与儿童变应性哮喘的相关分析
- Author:
Tianpen CUI
;
Lihua HU
;
Shixiu PAN
;
Dong XI
;
Jianmin WU
- Publication Type:Journal Article
- Keywords:
Asthma;
Interleukin-4;
Receptors,interleukin-4;
Immunoglobulin E
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine whether interleukin 4 and interleukin 4 receptor ? chain are associated with allergic asthma in children and to study the impact of such polymorphism upon plasma IgE.METHODS: Two polymorphism sites of IL-4 and IL-4R were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).RESULTS: (1)The results showed that the IL-4 promoter-589 was not associated with children allergic asthma, however, the IL-4R ? chain 576RR genotype and R allele were significantly increased in the subjects with asthma in children compared with age-matched control subjects (?2=11.84, P
