Effect of partial liquid ventilation with PFC on gas exchange and lung histopathology in piglets with acute lung injury
- VernacularTitle:部分液体通气对急性肺损伤小猪肺组织结构及气体交换的影响
- Author:
Xuemei PENG
;
Chan SUN
;
Huadong WANG
;
Yanqing XIAO
;
Zhonghong WANG
;
Liang YAN
;
Yanping WANG
- Publication Type:Journal Article
- Keywords:
Partial liquid ventilation;
Perfluorocarbon;
Acute lung injury;
Pathology
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of partial liquid ventilation on gas exchange and histopathological changes of lung in acute lung injury. METHODS: After acute lung injury (ALI) was induced by saline lavage,twenty piglets were assigned randomly to 2 groups: partial liquid ventilation with perfluorocarbon (PFC) group (PLV) and conventional gas ventilation group (CV). The changes of gas exchange were examined before ALI, during ALI and at 1,2,3,4 h after ALI, and histological sections taken from 8 different parts of lung were stained by H & E. RESULTS: The PaO_2 significantly increased and alveolar-aterial oxygen gradient (AaDO_2) markedly decreased in PLV group compare with CV group (P
