Relationship between MAT1 expression and clinicopathological features of pancreatic cancers
- VernacularTitle:胰腺癌中MAT1蛋白的表达与其临床病理特征的关系
- Author:
Jianping LIU
;
Shizhen YUAN
;
Shineng ZHANG
;
Jun ZHAN
;
Zhaohua ZHU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Cell cycle;
Protein MAT1;
Protein kinases
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of MAT1 protein in pancreatic cancers and the relationship between MAT1 and clinicopathological features of pancreatic cancers. METHODS: 94 surgical specimens, including 70 pancreatic cancers, 10 pancreatic benign tumors, 14 chronic pancreatitis and 10 autopsy normal pancreas tissues, were analyzed immunohistochemically, and then MAT1 expression and clinicopathological features were compared. RESULTS: MAT1 was expressed mainly in the cancer cells,and also in the fibroblasts, where it was localized within the cytoplasm and nuclear envelope. MAT1 expression was found in 75.7% (53/70) of the cancers, but not detected or weakly expressed in control tissues. There was a significant difference in expression of MAT1 among the above four tissues (P
