Effect of indomathacin on levels of PGE_2、PGI_2 and TXA_2 in experimentally inflamed pulp in rats
- VernacularTitle:消炎痛对创伤牙髓组织PGE_2、PGI_2和TXA_2抑制作用的实验研究
- Author:
Min XIE
;
Shiguang HUANG
;
Fangli L
- Publication Type:Journal Article
- Keywords:
Pulpitis;
Prostaglandins E;
Prostaglandins I;
Thromboxane A_2
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of local application of indomethacin on acute pulpitis. METHODS: Traumatic pulpitis model in rats was established by means of pulp exposure, radioimmunoassay (RIA) was used to measure the kinetic changes of the levels of PGE_2、6-keto-PGF_~1? and TXB_2 of pulpal tissues. RESULTS: Local application of indomethacin could more effectively inhibit the cyclo-oxygenase pathway than zinc oxide engenol in the early stage of pulpitis and reduce the production of prostaglandins. CONCLUSION: Local application of indomethacin may have a therapeutic effect on acute pulpitis. [
