The mechanism of profibrotic effect of connective tissue growth factor
- VernacularTitle:结缔组织生长因子促纤维化作用及其表达调节的研究进展
- Author:
Min YANG
;
Haichang HUANG
;
Haiyan WANG
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Fibrosis;
Transforming growth factor beta
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Connective tissue growth factor (CTGF) has recently received much attention as a possible key determinant of progressive fibrosis. It promotes tissue fibrosis through different pathways, such as cell proliferation, extracellular matrix accumulation and cell transdifferentiation. A number of regulators of CTGF expression have been identified, including transforming growth factor ?, vascular endothelial growth factor, tumor necrosis factor ?, etc. The mechanism of profibrotic effect by CTGF was reviewed. [
