Study of the Therapeutic Effect of8-methoxypsoralen Liposome Gel on Leukodermia in Guinea-pig Models
- VernacularTitle:8-甲氧补骨脂素脂质体凝胶对白癜风模型豚鼠的治疗作用研究
- Author:
Wen HE
;
Ruiling HAN
;
Shunde LUO
- Publication Type:Journal Article
- Keywords:
MOP;
Liposomal gel;
Vitiligo guinea-pig model;
Therapeutic effect
- From:
China Pharmacy
1991;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the therapeutic effects of8-methoxypsoralen(8-MOP)liposomal gel with other dosage forms of8-MOP in equal concentration on guinea-pig models of vitiligo.METHODS:The guinea-pigs were divided into normal control,model,8-MOP tincture,8-MOP gel and8-MOP liposome gel groups.The vitiligo model was established by chemical decoloration method in all groups except normal control group,then corresponding preparations were topically ap?plied.The therapeutic effects were compared and the melanogenesis of hair follicles,serum acetylcholinesterases and skin MDA contents were observed in all groups.RESULTS:8-MOP liposomal gel had better therapeutic effects on the animal models,and could improve the dermatic melanogenesis and acetylcholinesterase of the animal model,and also had effect on MDA of skin.The differences between8-MOP liposomal gel group and model group were highly significant(P
