Expression of nitric oxide synthase system in fetal rat kidney after acute ischemia(hypoxia)/reperfusion
- VernacularTitle:急性缺血缺氧及再灌注时胎鼠肾脏一氧化氮合酶体系的表达
- Author:
Mei HAN
;
Juan LI
;
Hong GAO
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Nitric oxide;
Nitric-oxide synthase;
Kidney
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of nitric oxide with nitric oxide synthase system in fetal rat kidney and the mechanism of renal injury after acute intrauterine ischemia(hypoxia)/reperfusion ischemia(hypoxia)/reperfusion. Methods Wistar rats of 21 gestational days were selected and divided into seven groups according to the different ischemia(hypoxia)/reperfusion time. The level of nitric oxide and the expression of nitric oxide synthase system were detected by biochemistry, immunohistochemistry and RT PCR. Results The NO level was decreased gradually with extension of ischemia, which was significantly different from sham group ( P
