A Study on the Effect of IL-2 Therapy on Chemotherapeutic Sensitivity in Hepatocelluar Carcinoma
- VernacularTitle:IL-2治疗对肝癌化疗敏感性影响的研究
- Author:
Wenzhuang SHEN
;
Jilin YI
;
Xingrui LI
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Multidrugs resistance-associated protein;
Interleukin-2
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the interleukin-2 (IL-2) treatment and chemotherapeutic sensitivity in hepatocellular carcinoma (HCC). Methods S-P immunohistochemical staining was adopted to determine the expression of multidrugs resistance-associated protein(MRP1) and IL-2 receptor ? chain in paraffin embedded HCC tissues of the patients treated with and without IL-2. Results The expression level of IL-2 receptor ?-chain in HCC tissues of the patients treated with and without IL-2 was 0.301 9?0.040 23 and 0.263 1?0.022 24, respectively, which had significant difference between the two kinds of HCC tissues. The expression level of MRP1 in the HCC tissues of the patients treated with IL-2 (0.336 4?0.044 67) was markedly higher than that in HCC tissues of the patients treated without IL-2 (0.300 8?0.037 64,t=2.176,P
