A Study on Apoptosis and Expression of Fas, bax and bcl-2 Proteins in Testicular Carcinoma
- VernacularTitle:细胞凋亡和相关基因Fas、bax和bcl-2蛋白在睾丸肿瘤中表达的研究
- Author:
Xiangan TU
;
Tang LAI
;
Keli ZHENG
- Publication Type:Journal Article
- Keywords:
Testicular neoplasm;
Apoptosis;
Gene
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of apoptosis and Fas, bax and bcl-2 proteins in the pathogenesis of testicular carcinoma. Methods Cell apoptosis was determined with TUNEL and flow cytometry, and the expression of Fas, bax and bcl-2 proteins were detected by cellular immunofluoresence technique in 56 cases of testicular carcinomas. Results Apoptotic index was closely correlated with the pathological type and lymph node metastasis of testicular carcinomas(P0.05). The apoptotic index was positively correlated with Fas and bax expression, and negatively correlated with bcl-2 expression (P
