The Effects of Antagonist of Angiotensin II Receptors on Rat Acute Pancreatitis
- VernacularTitle:AngII受体拮抗剂对急性胰腺炎影响的研究
- Author:
Kun LI
;
Xuncheng ZHANG
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Angiotensin II;
Antagonist;
Inflammation
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of antagonist of angiotensin II(Ang II) receptors on acute pancreatitis(AP) of rats. Methods The Sprague-Dawley rats were divided randomly into normal group, AP group, AP+lower dose of valsartan(5mg/kg) group , AP+higher dose of valsartan(8mg/kg) group, lower dose of valsartan group and higher dose of valsartan group, and each group containing 6 animals. AP animal models were induced by intraperitoneal injection of cerulein. Valsartan was given by intragastric administration. The histopathological changes of pancreas were observed and scored, and the pancreatic edema was evaluated. The levels of plasma amylase (AMY) and pancreatic myeloperoxidase (MPO) were measured. Results Compared with AP group, the pathologic lesions of pancreas and pancreatic edema decreased in the group AP+ valsartan, and the levels of plasma AMY and MPO also reduced. Conclusion Pretreatment with antagonist of angiotensin II receptors in rat acute pancreatitis can markedly reduce pancreatic injury and inflammation.
