The Prtective Effect of Exogenous Oxygen and Superoxide Dismutase on Acute Spinal Cord Injury
- VernacularTitle:外源性供氧和超氧化物歧化酶对脊髓损伤的保护作用
- Author:
Wanggou ZHENG
;
Weihong PAN
;
Gang WANG
- Publication Type:Journal Article
- Keywords:
Oxygen;
Superoxide dismutas;
Spinal cord injury;
Rabbit
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of exogenous oxygen and superoxide dismutase (SOD) on acute spinal cord injury. Methods A rabbit model of L2 spinal cord injury was produced by Allen's method, and then the rabbits were randomly divided into experimental group and control group. In the experimental group, the rabbits received exogenous oxygen, SOD or both 30 min after injury. 12h after injury, the amount of MDA and SOD of spinal tissues were determined, and pathological changes of spinal cord were observed at the fourth weeks after injury. Results Combinant administration of exogenous oxygen and SOD could inhibit MDA production and increase SOD activities, effect of which was stronger that single administration (P
