Expression and Significance of CA125 and CA15-3 in Human Breast Cancer
- VernacularTitle:乳腺癌中CA125、CA15-3的表达及其意义
- Author:
Boni DING
;
Daojin CHEN
;
Junhui WU
- Publication Type:Journal Article
- Keywords:
CA125;
CA15-3;
Breast cancer;
Diagnosis;
Prognosis
- From:
Journal of Chinese Physician
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectiv To investigate the expression and clinical significance of CA125 and CA15-3 in human breast cancer. Methods Radioimmunoassay method was used to determine the serum levels of CA125 and CA15-3 in 80 patients with breast carcinoma, 60 patients with benign breast diseases and 80 normal adults. Results The levels of serum CA125 and CA15-3 in patients with stage Ⅲ-Ⅳ breast carcinomas were significantly higher than those in patients with benign breast diseases,normal adults and stage Ⅰ～Ⅱ breast cancer patients (P0.05). Conclusion CA125 and CA15-3 are helpful to diagnose breast cancer, and can serve as a biological marker for monitoring tumor progression and evaluating prognosis in breast cancer.
