Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet.
- Author:
Young Rye KANG
1
;
Hak Yong LEE
;
Jung Hoon KIM
;
Dea In MOON
;
Min Young SEO
;
Sang Hoon PARK
;
Kwang Ho CHOI
;
Chang Ryong KIM
;
Sang Hyun KIM
;
Ji Hyun OH
;
Seong Wan CHO
;
Sun Young KIM
;
Min Gul KIM
;
Soo Wan CHAE
;
Okjin KIM
;
Hong Geun OH
Author Information
- Publication Type:Original Article
- Keywords: Yerba Mate; Ilex paraguariensis; anti-obesity effect; anti-diabetic effect; anti-cholesterol
- MeSH: Adipocytes; Adipose Tissue; Animals; Basal Metabolism; Body Weight; Cholesterol; Diet, High-Fat; Eating; Energy Metabolism; Food, Formulated; Glucose; Ilex paraguariensis; Lipid Metabolism; Mice; Models, Animal; Obesity; Tea; Trees; Triglycerides; Weight Loss
- From:Laboratory Animal Research 2012;28(1):23-29
- CountryRepublic of Korea
- Language:English
- Abstract: Yerba Mate, derived from the leaves of the tree, Ilex paraguariensis, is widely-used as a tea or as an ingredient in formulated foods. The aim of the present study was to evaluate the effects of Yerba Mate extract on weight loss, obesity-related biochemical parameters, and diabetes in high-fat diet-fed mice. To this end, by using in vivo animal models of dietary-induced obesity, we have made the interesting observations that Yerba Mate has the ability to decrease the differentiation of pre-adipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity. Our data from in vivo studies revealed that Yerba Mate treatment affects food intake, resulting in higher energy expenditure, likely as a result of higher basal metabolism in Yerba Mate-treated mice. Furthermore, in vivo effects of Yerba Mate on lipid metabolism included reductions in serum cholesterol, serum triglycerides, and glucose concentrations in mice that were fed a high fat diet. In conclusion, Yerba Mate can potentially be used to treat obesity and diabetes.
